Ontology highlight
ABSTRACT:
INSTRUMENT(S): micrOTOF II, Orbitrap Fusion, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Florian Stengel
LAB HEAD: Florian Stengel
PROVIDER: PXD020686 | Pride | 2021-07-20
REPOSITORIES: pride
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Nature communications 20210609 1
Decoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is well studied for PTMs of core histones but not for linker histone H1 in general and its ubiquitylation in particular due to a lack of proper tools. Here, we report on the chemical synthesis of site-specifically mono-ubiquitylated H1.2 and identify its ubiquitin-dependent interactome on a proteome-wide scale. We show that site-specific ubiquitylation o ...[more]