Proteomics

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Memory-enhancing effects of Origanum majorana essential oil in an Alzheimer's amyloid beta1-42 rat model: a molecular and behavioral study

ABSTRACT: Origanum L. (Lamiaceae) is an important genus of medicinal and aromatic plants used in the traditional medicine since ancient times as culinary herbs and remedies. The effects of Origanum majorana-based aromatherapy was investigated in an Alzheimer's amyloid beta1-42 rat model. Protein extracts from brain tissue containing hippocampi were analyzed by label-free quantitative LC-HDMSE. Proteins whose expression seemed influenced by Origanum majorana-based aromatherapy were assigned as representatives of biological processes, which were further targeted using well established biochemical/molecular assays.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain, Regional Part Of Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Stefan Mikkat  

LAB HEAD: Michael O. Glocker

PROVIDER: PXD021082 | Pride | 2020-09-29

REPOSITORIES: Pride

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Dataset's files

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Action DRS
11052015_HAbeta_digest_Postu_HDMSE_01.raw.zip Raw
11052015_HAbeta_digest_Postu_HDMSE_02.raw.zip Raw
11052015_HORG1_digest_Postu_HDMSE_01.raw.zip Raw
11052015_HORG1_digest_Postu_HDMSE_02.raw.zip Raw
11052015_HORG3_digest_Postu_HDMSE_01.raw.zip Raw
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Publications

Memory-Enhancing Effects of <i>Origanum majorana</i> Essential Oil in an Alzheimer's Amyloid beta1-42 Rat Model: A Molecular and Behavioral Study.

Postu Paula Alexandra PA   Gorgan Dragos Lucian DL   Cioanca Oana O   Russ Manuela M   Mikkat Stefan S   Glocker Michael Otto MO   Hritcu Lucian L  

Antioxidants (Basel, Switzerland) 20200926 10

<i>Origanum</i> L. (Lamiaceae) is an important genus of medicinal and aromatic plants used in traditional medicine since ancient times as culinary herbs and remedies. The aim of the present study was to evaluate the chemical composition, as well as the biochemical and cellular activities of freshly prepared <i>Origanum majorana</i> L. essential oil (OmEO) in an Alzheimer's disease (AD) amyloid beta1-42 (Aβ1-42) rat model. OmEO (1% and 3%) was inhaled for 21 consecutive days, while Aβ1-42 was adm  ...[more]

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