Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Joern Dengjel
LAB HEAD: Joern Dengjel
PROVIDER: PXD021109 | Pride | 2021-03-22
REPOSITORIES: Pride
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Dokládal Ladislav L Stumpe Michael M Pillet Benjamin B Hu Zehan Z Garcia Osuna Guillermo Miguel GM Kressler Dieter D Dengjel Jörn J De Virgilio Claudio C
Molecular cell 20210319 9
The conserved Gcn2 protein kinase mediates cellular adaptations to amino acid limitation through translational control of gene expression that is exclusively executed by phosphorylation of the α-subunit of the eukaryotic translation initiation factor 2 (eIF2α). Using quantitative phosphoproteomics, however, we discovered that Gcn2 targets auxiliary effectors to modulate translation. Accordingly, Gcn2 also phosphorylates the β-subunit of the trimeric eIF2 G protein complex to promote its associat ...[more]