Proteomics

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Deletion of miR-15a/16-1 in murine germinal center B-cells.

ABSTRACT: Given the tumor suppressing function of miR-15a/16-1 cluster, we studied its role in the germinal center B-cells that give rise to most lymphoid malignancies.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): B Cell, Lymph Node

DISEASE(S): Acute Leukemia

SUBMITTER: Tomasz Sewastianik  

LAB HEAD: Ruben D. Carrasco

PROVIDER: PXD021323 | Pride | 2021-09-09

REPOSITORIES: Pride

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180730ATSSAM04471_TMT10GC-FT1-20_UniprotMouseplusIsoforms2019_PSM.xlsx Xlsx
180730ATSSAM04471_TMT10GC-FT1.raw Raw
180730ATSSAM04471_TMT10GC-FT10.raw Raw
180730ATSSAM04471_TMT10GC-FT11.raw Raw
180730ATSSAM04471_TMT10GC-FT12.raw Raw
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Publications

Chromosome 13q deletion [del(13q)], harboring the miR-15a/16-1 cluster, is one of the most common genetic alterations in mature B-cell malignancies, which originate from germinal center (GC) and post-GC B cells. Moreover, miR-15a/16 expression is frequently reduced in lymphoma and multiple myeloma (MM) cells without del(13q), suggesting important tumor-suppressor activity. However, the role of miR-15a/16-1 in B-cell activation and initiation of mature B-cell neoplasms remains to be determined. W  ...[more]

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