Ontology highlight
ABSTRACT:
INSTRUMENT(S): ultraflex
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Hana Nuskova
LAB HEAD: Aurelio A. Teleman
PROVIDER: PXD021517 | Pride | 2021-07-22
REPOSITORIES: Pride
Action | DRS | |||
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181121AnalysisParameter.xml | Xml | |||
181121GNAI3endogenousacylation.zip | Other | |||
181121MascothomeGNAI3-GFPms1.mht | Other | |||
181121MascothomeGNAI3-GFPms2.mht | Other | |||
19030113C18_0.zip | Other |
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Nůsková Hana H Serebryakova Marina V MV Ferrer-Caelles Anna A Sachsenheimer Timo T Lüchtenborg Christian C Miller Aubry K AK Brügger Britta B Kordyukova Larisa V LV Teleman Aurelio A AA
Nature communications 20210728 1
Covalent attachment of C16:0 to proteins (palmitoylation) regulates protein function. Proteins are also S-acylated by other fatty acids including C18:0. Whether protein acylation with different fatty acids has different functional outcomes is not well studied. We show here that C18:0 (stearate) and C18:1 (oleate) compete with C16:0 to S-acylate Cys3 of GNAI proteins. C18:0 becomes desaturated so that C18:0 and C18:1 both cause S-oleoylation of GNAI. Exposure of cells to C16:0 or C18:0 shifts GNA ...[more]