Identifying the impact of cadmium stress on the pneumococcal metalloproteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Streptococcus Pneumoniae Serotype 2 (strain D39 / Nctc 7466)
SUBMITTER: 
Stephanie Neville
LAB HEAD: Christopher A. McDevitt
PROVIDER: PXD021643 | Pride | 2021-06-25
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 141009_amber_ua_f34.raw | Raw | |||
| FTerlfTOT.mgf | Mgf | |||
| FTerlfTaS.mgf | Mgf | |||
| FTerlfTnO.mgf | Mgf | |||
| FTerlfTne.mgf | Mgf |
Items per page: 5 1 - 5 of 49 |
Publications
Cadmium stress dictates central carbon flux and alters membrane composition in Streptococcus pneumoniae.
Neville Stephanie L SL Eijkelkamp Bart A BA Lothian Amber A Paton James C JC Roberts Blaine R BR Rosch Jason W JW McDevitt Christopher A CA
Communications biology 20201119 1
Metal ion homeostasis is essential for all forms of life. However, the breadth of intracellular impacts that arise upon dysregulation of metal ion homeostasis remain to be elucidated. Here, we used cadmium, a non-physiological metal ion, to investigate how the bacterial pathogen, Streptococcus pneumoniae, resists metal ion stress and dyshomeostasis. By combining transcriptomics, metabolomics and metalloproteomics, we reveal that cadmium stress dysregulates numerous essential cellular pathways in ...[more]
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