Dataset Information

TRIM9 and TRIM67 interactome using the BioID approach

ABSTRACT: TRIM9 and TRIM67 are two brain enriched E3 uiquitin ligases that are critical to neuronal form and function both during embryonic development and in adult-born neurons. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome is not known.Using the BioID approach we have identified potential TRIM9 aand TRIM67 interaction partners.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Neuron, Primary Cell

SUBMITTER: Stephanie Gupton

LAB HEAD: Stephanie L. Gupton

PROVIDER: PXD021758 | Pride | 2021-01-04

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	GU001_MycBirA_mouse_control.raw	Raw
	GU002_MycBirA_TRIM9_mouse_Shalini.raw	Raw
	GU003_MycBirA_TRIM67_mouse_Shalini.raw	Raw
	GU028_MycBirA_mouse_biotin_Shalini.raw	Raw
	GU029_MouseNeurons_Trim9deltaRING_BirA_Shalini_1ul.raw	Raw

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Publications

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

Menon Shalini S Goldfarb Dennis D Ho Chris T CT Cloer Erica W EW Boyer Nicholas P NP Hardie Christopher C Bock Andrew J AJ Johnson Emma C EC Anil Joel J Major M Ben MB Gupton Stephanie L SL

Molecular biology of the cell 20201230 4

TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate morphogenesis of cortical and hippocampal neurons and fidelitous responses to the axon guidance cue netrin-1. Deletion of murine <i>Trim9</i> or <i>Trim67</i> results in neuroanatomical defects and striking behavioral deficits, particularly in spatial learning and memory. TRIM9 and TRIM67 interact with cytoskeletal and exocytic proteins, but the full interactome is not known. Here we performed the unbiased pr ...[more]

PMID: 33378226

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