Proteomics

Dataset Information

0

NALCN crosslinking experiments by BS3 crosslinker

ABSTRACT: We used BS3 as the crosslinker to identify the crosslinking sites between NALCN and other interacted proteins.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Shan Feng  

LAB HEAD: Shan Feng

PROVIDER: PXD022119 | Pride | 2020-12-04

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
MS2000225_BS3_after_20200521105326.cross-linked.BS3.plabel Other
MS2000225_BS3_after_20200521105326.loop-linked.BS3.plabel Other
MS2000225_BS3_after_20200521105326.mono-linked.BS3.plabel Other
MS2000225_BS3_after_20200521105326.mzML Mzml
MS2000225_BS3_after_20200521105326.raw Raw
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Publications

Structure of the human sodium leak channel NALCN in complex with FAM155A.

Xie Jiongfang J   Ke Meng M   Xu Lizhen L   Lin Shiyi S   Huang Jin J   Zhang Jiabei J   Yang Fan F   Wu Jianping J   Yan Zhen Z  

Nature communications 20201117 1

NALCN, a sodium leak channel expressed mainly in the central nervous system, is responsible for the resting Na<sup>+</sup> permeability that controls neuronal excitability. Dysfunctions of the NALCN channelosome, NALCN with several auxiliary subunits, are associated with a variety of human diseases. Here, we report the cryo-EM structure of human NALCN in complex with FAM155A at an overall resolution of 3.1 angstroms. FAM155A forms extensive interactions with the extracellular loops of NALCN that  ...[more]

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