Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Astrocyte
DISEASE(S): Amyotrophic Lateral Sclerosis
SUBMITTER: Oliver Ziff
LAB HEAD: Rickie Patani
PROVIDER: PXD022604 | Pride | 2021-09-09
REPOSITORIES: Pride
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ac_vcp_fractions_mass_spectrometry.xlsx | Xlsx | |||
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Ziff Oliver J OJ Taha Doaa M DM Crerar Hamish H Clarke Benjamin E BE Chakrabarti Anob M AM Kelly Gavin G Neeves Jacob J Tyzack Giulia E GE Luscombe Nicholas M NM Patani Rickie R
Nucleic acids research 20210401 6
Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human-induced pluripotent stem cell (hiPSC)-derived astrocytes carrying ALS-causing mutations in VCP, SOD1 and C9orf72. Notably, transcripts with decreased IR and increased expression are overrepresented in reactivity processes including cell adhesion, stress response and immune activation. Th ...[more]