Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human) Drosophila Melanogaster (fruit Fly) Mus Musculus (mouse)
TISSUE(S): Blood Cell
DISEASE(S): Acute Leukemia
SUBMITTER: Jarrod Sandow
LAB HEAD: Ricky Johnstone
PROVIDER: PXD022962 | Pride | 2022-08-12
REPOSITORIES: Pride
Action | DRS | |||
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170717_Colin_CH1.raw | Raw | |||
170717_Colin_CH3.raw | Raw | |||
170817_Ben_1.raw | Raw | |||
170817_Ben_2.raw | Raw | |||
170817_Ben_3.raw | Raw |
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Cell 20210517 12
Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The pausing checkpoint following transcription initiation is primarily controlled by CDK9. We discovered that CDK9-mediated, RNAPII-driven transcription is functionally opposed by a protein phosphatase 2A (PP2A) complex that is recruited to transcription sites by the Integrator complex subunit INTS6. PP2A dynamically antagonizes phosphoryl ...[more]