Proteomics

Dataset Information

0

Proteome adaptations of AC16 cells different oxygen exposure


ABSTRACT: To simulate in vitro different oxidative stress exposures, AC16 cells were cultured either under physioxia (5% oxygen) or normoxia (21% oxygen), and were consequently harvested either under physioxia or normoxia.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Tamara Tomin  

LAB HEAD: Ruth Birner-Gruenberger

PROVIDER: PXD023620 | Pride | 2021-09-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
SPhumanCr-2019.fasta Fasta
TT_20200630_N2_BB1_01_16178.baf Other
TT_20200630_N3_BC1_01_16196.baf Other
TT_20200630_N4_BD1_01_16214.baf Other
TT_20200630_PN1_BA6_01_16168.baf Other
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Publications

Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts.

Tomin Tamara T   Schittmayer Matthias M   Sedej Simon S   Bugger Heiko H   Gollmer Johannes J   Honeder Sophie S   Darnhofer Barbara B   Liesinger Laura L   Zuckermann Andreas A   Rainer Peter P PP   Birner-Gruenberger Ruth R  

International journal of molecular sciences 20210211 4


Oxidative stress contributes to detrimental functional decline of the myocardium, leading to the impairment of the antioxidative defense, dysregulation of redox signaling, and protein damage. In order to precisely dissect the changes of the myocardial redox state correlated with oxidative stress and heart failure, we subjected left-ventricular tissue specimens collected from control or failing human hearts to comprehensive mass spectrometry-based redox and quantitative proteomics, as well as glu  ...[more]

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