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Analysis of mouse liver secretome and proteome during nonalcoholic steatohepatitis

ABSTRACT: Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. Using proteomic approaches, we interrogated hepatocyte protein secretion in two models of murine NASH to reveal striking hepatokine remodelling that is associated with insulin resistance and maladaptive lipid metabolism.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

DISEASE(S): Non-alcoholic Steatohepatitis

SUBMITTER: Benjamin Parker

LAB HEAD: Benjamin Parker

PROVIDER: PXD024673 | Pride | 2022-02-27

REPOSITORIES: Pride

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			Action	DRS
	191224_Magda_MM-307_CHOL_1.raw	Raw
	191224_Magda_MM-307_CHOL_6.raw	Raw
	191224_Magda_MM-307_CHOL_7.raw	Raw
	191224_Magda_MM-307_CHOL_8.raw	Raw
	191224_Magda_MM-307_CHOL_control1.raw	Raw

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