Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Emilio Cirri
LAB HEAD: Steve Hoffmann
PROVIDER: PXD024869 | Pride | 2023-03-11
REPOSITORIES: pride
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Schwab Katjana K Coronel Luis L Riege Konstantin K Sacramento Erika K EK Rahnis Norman N Häckes David D Cirri Emilio E Groth Marco M Hoffmann Steve S Fischer Martin M
Cell death discovery 20230303 1
Recurrently mutated in lymphoid neoplasms, the transcription factor RFX7 is emerging as a tumor suppressor. Previous reports suggested that RFX7 may also have a role in neurological and metabolic disorders. We recently reported that RFX7 responds to p53 signaling and cellular stress. Furthermore, we found RFX7 target genes to be dysregulated in numerous cancer types also beyond the hematological system. However, our understanding of RFX7's target gene network and its role in health and disease r ...[more]