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Proteome of C. elegans upon NCL-1 or TIF-IA KD during aging

ABSTRACT: Anabolic activities such as ribosome biogenesis and protein synthesis are linked to aging. Ribosomal RNA (rRNA) synthesis is the limiting step of ribosome biogenesis, thus dictating the number of ribosomes in cells and, consequently, the capacity for mRNA translation. Knockdown of the rRNA synthesis repressor, NCL-1, accelerated aging, whereas knocking down the transcription initiation factor C36E8.1 promoted longevity. This suggested that rRNA synthesis has a negative correlation with lifespan. To investigate the metabolic changes upon manipulation of rRNA synthesis the proteome of NCL-1 KD and C36E8.1 KD were analyzed at young, middle, and old age (AD2, AD6, AD12).

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Emilio Cirri

LAB HEAD: Dr. Holger

PROVIDER: PXD028600 | Pride | 2024-01-11

REPOSITORIES: Pride

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			Action	DRS
	181224_HFX_JMK_NR_SamS_worms_DIA_C36D12_rep1_26.raw	Raw
	181224_HFX_JMK_NR_SamS_worms_DIA_C36D12_rep2_27.raw	Raw
	181224_HFX_JMK_NR_SamS_worms_DIA_C36D12_rep3_28.raw	Raw
	181224_HFX_JMK_NR_SamS_worms_DIA_C36D12_rep4_29.raw	Raw
	181224_HFX_JMK_NR_SamS_worms_DIA_C36D12_rep5_30.raw	Raw

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