Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Optic Nerve
DISEASE(S): Multiple Sclerosis
SUBMITTER: Sanjoy Bhattacharya
LAB HEAD: Sanjoy Bhattacharya
PROVIDER: PXD024966 | Pride | 2022-02-17
REPOSITORIES: Pride
Action | DRS | |||
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ITRAQ.mzML | Mzml | |||
ITRAQ.mzid.gz | Mzid | |||
ITRAQ.raw | Raw | |||
ITRAQ_R2.mzML | Mzml | |||
ITRAQ_R2.mzid.gz | Mzid |
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Valdivia Anddre Osmar AO Bhattacharya Sanjoy K SK
eNeuro 20220126 1
Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our <i>in vitro</i> studies show LPC 18:1 protection against neuron-ectopic hyperdeimination and stimulation of oligodendrocyte maturation, while <i>in vivo ...[more]