Proteomics

Dataset Information

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BioID-based proteomic analysis of CARP3-proximal proteins in Trypanosoma brucei bloodstream forms


ABSTRACT: How flagellar signaling regulates the host interaction of parasites remains a challenge due to poor conservation of signaling systems with those in cilia of higher organisms. The trypanosome-specific cAMP response protein 3 (CARP3) shows developmentally regulated localization at the flagellar tip membrane, where it is essential for parasite swarming and colonization of the tsetse fly insect vector. This project describes a proximity-dependent proteomics approach (BioID) that identified proteins in close vicinity of CARP3 in the bloodstream stage of Trypanosoma brucei.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Trypanosoma Brucei

SUBMITTER: Dupuy Jean-William  

LAB HEAD: Michael Boshart

PROVIDER: PXD025357 | Pride | 2022-08-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Link_between_files.xlsx Xlsx
TriTrypDB-51_TbruceiTREU927_AnnotatedProteins.fasta Fasta
andromeda.zip Other
checksum.txt Txt
mb161027_01.raw Raw
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Publications


Signaling from ciliary microdomains controls developmental processes in metazoans. Trypanosome transmission requires development and migration in the tsetse vector alimentary tract. Flagellar cAMP signaling has been linked to parasite social motility (SoMo) in vitro, yet uncovering control of directed migration in fly organs is challenging. Here we show that the composition of an adenylate cyclase (AC) complex in the flagellar tip microdomain is essential for tsetse salivary gland (SG) colonizat  ...[more]

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