Proteomics

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Quantitative proteomics upon CARP3 knock down in Trypanosoma brucei bloodstream forms

ABSTRACT: How flagellar signaling regulates the host interaction of parasites remains a challenge due to poor conservation of signaling systems with those in cilia of higher organisms. The trypanosome-specific cAMP response protein 3 (CARP3) shows developmentally regulated localization at the flagellar tip membrane, where it is essential for parasite swarming and colonization of the tsetse fly insect vector. This project describes a label-free, quantitative proteomics approach that identifies proteins changing in abundance upon inducible CARP3 knock down in bloodstream stage Trypanosoma brucei.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Trypanosoma Brucei Brucei

SUBMITTER: Ignasi Forne  

LAB HEAD: Boshart, Michael

PROVIDER: PXD025401 | Pride | 2022-08-31

REPOSITORIES: Pride

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Ref2950_MB_SB_2i_20200204.raw Raw
Ref2950_MB_SB_2u_20200204.raw Raw
Ref2950_MB_SB_3i_20200204.raw Raw
Ref2950_MB_SB_3u_20200204.raw Raw
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Publications

Signaling from ciliary microdomains controls developmental processes in metazoans. Trypanosome transmission requires development and migration in the tsetse vector alimentary tract. Flagellar cAMP signaling has been linked to parasite social motility (SoMo) in vitro, yet uncovering control of directed migration in fly organs is challenging. Here we show that the composition of an adenylate cyclase (AC) complex in the flagellar tip microdomain is essential for tsetse salivary gland (SG) colonizat  ...[more]

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