Proteomics

Dataset Information

0

Comprehensive proteomics for Discovery vaccine candidates against Streptococcus equi Infections


ABSTRACT: Streptococcus equi subspecies equi (S. equi) is a major pathogen which cause strangles, a highly contagious respiratory infection, in horses and other equines. In this study, we purified the extracellular vesicles (EVs) of S. equi ATCC 39506 and evaluated them as vaccine candidates against S. equi infections in mice. Through immunization in an animal model and immunoprecipitation-mass spectrometry, we evaluated EV as vaccine candidates against S. equi infections and identified novel immunogenic proteins.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Streptococcus Equi Subsp. Equi Mus Musculus (mouse)

SUBMITTER: Hayoung Lee  

LAB HEAD: Seung Il Kim

PROVIDER: PXD025527 | Pride | 2021-08-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
F002598.mgf Mgf
F002599.mgf Mgf
SequiATCC39506_IP_G2.mzid.gz Mzid
SequiATCC39506_IP_G2_1.raw Raw
SequiATCC39506_IP_G2_2.raw Raw
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Publications

Streptococcus equi-derived extracellular vesicles as a vaccine candidate against Streptococcus equi infection.

Lee Hayoung H   Yun Sung Ho SH   Hyon Ju-Yong JY   Lee Sang-Yeop SY   Yi Yoon-Sun YS   Choi Chi-Won CW   Jun Sangmi S   Park Edmond Changkyun EC   Kim Seung Il SI  

Veterinary microbiology 20210625


Streptococcus equi subspecies equi is a pathogenic bacterium that causes strangles, a highly contagious respiratory infection in horses and other equines. The limitations of current vaccines against S. equi infection warrants the development of an affordable, safe, and effective vaccine. Because gram-positive extracellular vesicles (EVs) transport various immunogenic antigens, they are attractive vaccine candidates. Here, we purified the EVs of S. equi ATCC 39506 and evaluated them as a vaccine  ...[more]

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