Proteomics

Dataset Information

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Human NSCLC DIA proteomics validation cohort 2

ABSTRACT: In this project, one NSCLC cohorts were analyzed by Data Independent Acquisition (DIA-MS). A cohort of early stage NSCLC samples (207) with the aim to demonstrate utility of MS for subtyping and treatment prediction in a clinical setting. Further, six identified NSCLC proteome subtypes were investigated in relation to cancer driver pathways and immune phenotypes based on the generated MS-data.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Non-small Cell Lung Carcinoma

SUBMITTER: Georgios Mermelekas  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD025560 | Pride | 2021-09-13

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20210129_GMLOOB_reprep_rerun_sample196.raw Raw
GMLOOB_DIA_5ug_3hrgrad_sample01.raw Raw
GMLOOB_DIA_5ug_3hrgrad_sample02.raw Raw
GMLOOB_DIA_5ug_3hrgrad_sample03.raw Raw
GMLOOB_DIA_5ug_3hrgrad_sample04.raw Raw
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Publications

Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms.

Lehtiö Janne J   Arslan Taner T   Siavelis Ioannis I   Pan Yanbo Y   Socciarelli Fabio F   Berkovska Olena O   Umer Husen M HM   Mermelekas Georgios G   Pirmoradian Mohammad M   Jönsson Mats M   Brunnström Hans H   Brustugun Odd Terje OT   Purohit Krishna Pinganksha KP   Cunningham Richard R   Foroughi Asl Hassan H   Isaksson Sofi S   Arbajian Elsa E   Aine Mattias M   Karlsson Anna A   Kotevska Marija M   Gram Hansen Carsten C   Drageset Haakensen Vilde V   Helland Åslaug Å   Tamborero David D   Johansson Henrik J HJ   Branca Rui M RM   Planck Maria M   Staaf Johan J   Orre Lukas M LM  

Nature cancer 20211122 11

Despite major advancements in lung cancer treatment, long-term survival is still rare, and a deeper understanding of molecular phenotypes would allow the identification of specific cancer dependencies and immune evasion mechanisms. Here we performed in-depth mass spectrometry (MS)-based proteogenomic analysis of 141 tumors representing all major histologies of non-small cell lung cancer (NSCLC). We identified six distinct proteome subtypes with striking differences in immune cell composition and  ...[more]

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