Proteomics

Dataset Information

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HDX-MS analysis of PLIN3 membrane binding

ABSTRACT: Hydrogen deuterium exchange mass spectrometry of PLIN3 in the presence of three different membrane vesicles to analyze structural changes induced by membrane binding.

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: John Burke  

LAB HEAD: John Burke

PROVIDER: PXD025717 | Pride | 2023-04-14

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
01_10_2020_BMHDX11_Apo_3000s_1_0_01_14857.d.zip Other
01_10_2020_BMHDX11_Apo_300s_1_0_01_14853.d.zip Other
01_10_2020_BMHDX11_Apo_30s_1_0_01_14849.d.zip Other
01_10_2020_BMHDX11_Apo_30s_2_0_01_14864.d.zip Other
01_10_2020_BMHDX11_Apo_3s_1_0_01_14845.d.zip Other
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Publications

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation.

Choi Yong Mi YM   Ajjaji Dalila D   Fleming Kaelin D KD   Borbat Peter P PP   Jenkins Meredith L ML   Moeller Brandon E BE   Fernando Shaveen S   Bhatia Surita R SR   Freed Jack H JH   Burke John E JE   Thiam Abdou Rachid AR   Airola Michael V MV  

Nature communications 20230602 1

Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated proteins called perilipins (PLINs). During LD biogenesis, perilipin 3 (PLIN3) is recruited to nascent LDs as they emerge from the endoplasmic reticulum. Here, we analyze how lipid composition affects PLIN3 recruitment to membrane bilayers and LDs, and the structural changes that occur upon membrane binding. We find that the T  ...[more]

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