Dataset Information

HDX-MS Analysis of the PI4K EFR3A Complex

ABSTRACT: HDX-MS analysis examining the complex that forms between the subunits of PI4KIIIa and EFR3A

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: John Burke

LAB HEAD: Dr. John E Burke

PROVIDER: PXD043442 | Pride | 2025-03-10

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	05_09_23_MPHDX31_ETF_0.3s_1_0_01_21975.d.zip	Other
	05_09_23_MPHDX31_ETF_300s_1_0_01_21986.d.zip	Other
	05_09_23_MPHDX31_ETF_30s_1_0_01_21983.d.zip	Other
	05_09_23_MPHDX31_ETF_40pm_MSMS_0_01_21978.d.zip	Other
	05_09_23_MPHDX31_E_0.3s_1_0_01_21976.d.zip	Other

Items per page:

1 - 5 of 104

Publications

Molecular basis for plasma membrane recruitment of PI4KA by EFR3.

Suresh Sushant S Shaw Alexandria L AL Pemberton Joshua G JG Scott Mackenzie K MK Harris Noah J NJ Parson Matthew A H MAH Jenkins Meredith L ML Rohilla Pooja P Alvarez-Prats Alejandro A Balla Tamas T Yip Calvin K CK Burke John E JE

Science advances 20241220 51

The lipid kinase phosphatidylinositol 4 kinase III α (PI4KIIIα/PI4KA) is a master regulator of the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a heterotrimeric complex with its regulatory proteins TTC7 and FAM126. Fundamental to PI4KA activity is its targeted recruitment to the plasma membrane by the lipidated proteins EFR3A and EFR3B. Here, we report a cryogenic electron microscopy structure of the C terminus of EFR3A bound to the PI4KA-TTC7B-FAM126A comple ...[more]

PMID: 39705356

Dataset Information

HDX-MS Analysis of the PI4K EFR3A Complex

Dataset's files

Publications

Molecular basis for plasma membrane recruitment of PI4KA by EFR3.

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