Proteomics

Dataset Information

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Protein profiling of Aortic-Valvular and Endocardial endothelial cells using label-free proteomics


ABSTRACT: The variations in the protein profile of aortic-valvular (AVE) and endocardial endothelial (EE) cells are currently unknown. The current study's objective is to identify differentially expressed proteins and associated pathways in both endothelial cells. We used endothelial cells isolated from the porcine aortic valve and endocardium for the profiling of proteins. Label-free proteomics was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Our proteomics analysis revealed that 29 proteins were highly expressed, and 25 proteins were less represented in the valve than endocardial endothelium. The first part of the study was already available in the ProteomeXchange Consortium (PXD009194).

INSTRUMENT(S): Synapt MS

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart, Cell Culture, Endothelial Cell, Aortic Endothelial Cell

DISEASE(S): Cardiovascular System Disease

SUBMITTER: MAHESH CHANDRAN V R  

LAB HEAD: Dr.Abdul Jaleel K.A

PROVIDER: PXD025922 | Pride | 2022-02-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20130805_PVEC1_01.raw.zip Raw
20130805_PVEC1_02.raw.zip Raw
20130805_PVEC1_03.raw.zip Raw
20130805_PVEC2_01.raw.zip Raw
20130805_PVEC2_02.raw.zip Raw
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Publications

Proteomics Analysis Reveals Diverse Molecular Characteristics between Endocardial and Aortic-Valvular Endothelium.

Aneesh Kumar A A   Ajith Kumar G S GS   Satheesh Gopika G   Surendran Arun A   Chandran Mahesh M   Kartha Chandrasekharan C CC   Jaleel Abdul A  

Genes 20210630 7


The variations in the protein profile of aortic-valvular (AVE) and endocardial endothelial (EE) cells are currently unknown. The current study's objective is to identify differentially expressed proteins and associated pathways in both the endothelial cells. We used endothelial cells isolated from the porcine (<i>Sus scrofa</i>) aortic valve and endocardium for the profiling of proteins. Label-free proteomics was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Our proteom  ...[more]

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