Proteomics

Dataset Information

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Multi-omics characterization of recurrent exertional rhabdomyolysis in Standardbred horses

ABSTRACT: During an episode of acute rhabdomyolysis, a microarray study identified differential expression of calcium-regulatory, mitochondrial and metabolic genes in gluteal muscle of Standardbreds. Whether this represents expression related to acute myodegeneration or a specific molecular signature of susceptibility to recurrent exertional rhabdomyolysis (RER) is currently unknown. We compared gluteal muscle histopathology, gene/protein expression and antioxidant concentrations between Standardbreds with a history of, but not currently experiencing rhabdomyolysis, and race-trained controls to derive a molecular susceptibility profile.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Gluteal Muscle

SUBMITTER: Stephanie Valberg  

LAB HEAD: Stephanie Valberg

PROVIDER: PXD026121 | Pride | 2023-03-11

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
RER-Standardbred-SDRF.tsv Tabular
Valberg - Gardner TMT11 Data Q+ 20200313.sf3 Other
Valberg_methods_20200313.doc Other
checksum.txt Txt
hf2020031918.mzid.gz Mzid
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Publications

Enriched Pathways of Calcium Regulation, Cellular/Oxidative Stress, Inflammation, and Cell Proliferation Characterize Gluteal Muscle of Standardbred Horses between Episodes of Recurrent Exertional Rhabdomyolysis.

Valberg Stephanie J SJ   Velez-Irizarry Deborah D   Williams Zoë J ZJ   Henry Marisa L ML   Iglewski Hailey H   Herrick Keely K   Fenger Clara C  

Genes 20221014 10

Certain Standardbred racehorses develop recurrent exertional rhabdomyolysis (RER-STD) for unknown reasons. We compared gluteal muscle histopathology and gene/protein expression between Standardbreds with a history of, but not currently experiencing rhabdomyolysis (<i>N</i> = 9), and race-trained controls (<i>N</i> = 7). Eight RER-STD had a few mature fibers with small internalized myonuclei, one out of nine had histologic evidence of regeneration and zero out of nine degeneration. However, RER-S  ...[more]

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