Proteomics

Dataset Information

0

Multi-omics characterization of recurrent exertional rhabdomyolysis in Standardbred horses

ABSTRACT: During an episode of acute rhabdomyolysis, a microarray study identified differential expression of calcium-regulatory, mitochondrial and metabolic genes in gluteal muscle of Standardbreds. Whether this represents expression related to acute myodegeneration or a specific molecular signature of susceptibility to recurrent exertional rhabdomyolysis (RER) is currently unknown. We compared gluteal muscle histopathology, gene/protein expression and antioxidant concentrations between Standardbreds with a history of, but not currently experiencing rhabdomyolysis, and race-trained controls to derive a molecular susceptibility profile.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Gluteal Muscle

SUBMITTER: Stephanie Valberg  

LAB HEAD: Stephanie Valberg

PROVIDER: PXD026121 | Pride | 2023-03-11

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
RER-Standardbred-SDRF.tsv Tabular
Valberg - Gardner TMT11 Data Q+ 20200313.sf3 Other
Valberg_methods_20200313.doc Other
checksum.txt Txt
hf2020031918.mzid.gz Mzid
Items per page:
1 - 5 of 7
altmetric image

Publications

Enriched Pathways of Calcium Regulation, Cellular/Oxidative Stress, Inflammation, and Cell Proliferation Characterize Gluteal Muscle of Standardbred Horses between Episodes of Recurrent Exertional Rhabdomyolysis.

Valberg Stephanie J SJ   Velez-Irizarry Deborah D   Williams Zoë J ZJ   Henry Marisa L ML   Iglewski Hailey H   Herrick Keely K   Fenger Clara C  

Genes 20221014 10

Certain Standardbred racehorses develop recurrent exertional rhabdomyolysis (RER-STD) for unknown reasons. We compared gluteal muscle histopathology and gene/protein expression between Standardbreds with a history of, but not currently experiencing rhabdomyolysis (<i>N</i> = 9), and race-trained controls (<i>N</i> = 7). Eight RER-STD had a few mature fibers with small internalized myonuclei, one out of nine had histologic evidence of regeneration and zero out of nine degeneration. However, RER-S  ...[more]

Similar Datasets

Proteomics Equine gluteal muscle LC-MSMS: Thoroughbred
2021-01-07 | PXD020100 | Pride
Transcriptomics Transcriptome analysis of muscle in horses suffering from recurrent exertional rhabdomyolysis revealed energetic pathway alterations and disruption in the cytoplasmic calcium regulation
2010-12-15 | E-GEOD-26047 | biostudies-arrayexpress
Transcriptomics Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle
2016-07-22 | E-GEOD-74570 | biostudies-arrayexpress
Transcriptomics AMPKα stimulates skeletal muscle fatty acid utilization during in vivo exercise in mice
2015-09-30 | GSE61904 | GEO
Transcriptomics Differential expression of skeletal muscle genes between normal and pale, soft and exudative (PSE) turkey meat.
2013-03-20 | E-GEOD-36660 | biostudies-arrayexpress
Methylation profiling Methylation studies in horses
2021-11-25 | GSE174767 | GEO
Transcriptomics Gene Expression differences between replication error deficient and proficient colorectal cancers: the dominant role of deletions in 3’UTR poly T sequences
2010-10-19 | E-GEOD-24795 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse myotubes infected with PGCalpha
2019-11-17 | E-MTAB-8457 | biostudies-arrayexpress
Transcriptomics Gene Expression differences between replication error deficient and proficient colorectal cancers: the dominant role of deletions in 3’UTR poly T sequences
2010-10-19 | GSE24795 | GEO
Transcriptomics RNA-Seq identifies differential gene expression associated with risk-genotype for Rhodococcus equi pneumonia in horses
2016-05-25 | GSE81858 | GEO