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Proteomics of cardiac stromal cells and dermal fibroblasts secretomes

ABSTRACT: The proteomics characterization of the secretomes as well as the evaluation of their potential to induce cell and tissue responses are widely used strategies. Here are presented the mass spectrometry data of the resident cardiac stromal cells (CRSC) and dermal fibroblasts secretomes, which enables the comparison of their compositions.

INSTRUMENT(S): LTQ Orbitrap XL ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Fibroblast Of Dermis, Stromal Cell

SUBMITTER: Michel Batista

LAB HEAD: Alessandra Melo de Aguiar

PROVIDER: PXD026451 | Pride | 2022-02-07

REPOSITORIES: Pride

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Secretome from resident cardiac stromal cells stimulates proliferation, cardiomyogenesis and angiogenesis of progenitor cells.

Reus Thamile Luciane TL Robert Anny Waloski AW Da Costa Marise Brenner Affonso MB de Aguiar Alessandra Melo AM Stimamiglio Marco Augusto MA

International journal of cardiology 20160630

In the heart, tissue-derived signals play a central role on recruiting/activating stem cell sources to induce cardiac lineage specification for maintenance of tissue homeostasis and repair. Cardiac resident stromal cells (CRSCs) may play a pivotal role in cardiac repair throughout their secretome. Here, we performed the characterization of CRSCs and their secretome by analyzing the composition of their culture-derived extracellular matrix (ECM) and conditioned medium (CM) and by investigating th ...[more]

PMID: 27404713

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