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Matrisome of neonatal mouse dermal fibroblasts

ABSTRACT: The goal of this project is to compare the protein composition of the extracellular matrices (ECMs) deposited in vitro by wild type, heterozygous, or SPAG17 KO neonatal mouse dermal fibroblasts.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Fibroblast, Skin Fibroblast

SUBMITTER: George Chlipala

LAB HEAD: Alexandra Naba

PROVIDER: PXD019869 | Pride | 2022-09-22

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	142_2.dat	Other
	142_2.mgf	Mgf
	142_2.mzid.gz	Mzid
	142_2.raw	Raw
	167-1.dat	Other

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Publications

Reduced SPAG17 Expression in Systemic Sclerosis Triggers Myofibroblast Transition and Drives Fibrosis.

Sapao Paulene P Roberson Elisha D O EDO Shi Bo B Assassi Shervin S Skaug Brian B Lee Fred F Naba Alexandra A Perez White Bethany E BE Córdova-Fletes Carlos C Tsou Pei-Suen PS Sawalha Amr H AH Gudjonsson Johann E JE Ma Feiyang F Verma Priyanka P Bhattacharyya Dibyendu D Carns Mary M Strauss Jerome F JF Sicard Delphine D Tschumperlin Daniel J DJ Champer Melissa I MI Campagnola Paul J PJ Teves Maria E ME Varga John J

The Journal of investigative dermatology 20220915 2

Systemic sclerosis (SSc) is a clinically heterogeneous fibrotic disease with no effective treatment. Myofibroblasts are responsible for unresolving synchronous skin and internal organ fibrosis in SSc, but the drivers of sustained myofibroblast activation remain poorly understood. Using unbiased transcriptome analysis of skin biopsies, we identified the downregulation of SPAG17 in multiple independent cohorts of patients with SSc, and by orthogonal approaches, we observed a significant negative c ...[more]

PMID: 36116512

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Xrn1 biochemically associates to the eisosome after the post diauxic shift in yeast (3)

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Xrn1 biochemically associates to the eisosome after the post diauxic shift in yeast (2)

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Dental Pulp Stem Cells LC-MS/MS analysis

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2021-09-23 | PXD018951 | Pride

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