Proteomics

Dataset Information

0

Transforming growth factor receptor beta 3 (TGFBR3)-associated membranous nephropathy


ABSTRACT: We utilized mass spectrometry for protein discovery through enrichment of glomerular proteins by laser capture microdissection and through elution of immune complexes within MLN biopsies.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

SUBMITTER: Aaron Storey  

LAB HEAD: Chris Larsen

PROVIDER: PXD026506 | Pride | 2022-05-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
112318_OCT_IP_008.raw Raw
112318_OCT_IP_008__F009256_.mzid.gz Mzid
112318_OCT_IP_008__F009256_.mzid_112318_OCT_IP_008__F009256_.MGF Mzid
112318_OCT_IP_029.raw Raw
112318_OCT_IP_029__F009255_.mzid.gz Mzid
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Publications


<h4>Background</h4>Membranous lupus nephritis (MLN) comprises 10%-15% of lupus nephritis and increases morbidity and mortality of patients with SLE through complications of nephrotic syndrome and chronic kidney failure. Identification of the target antigens in MLN may enable noninvasive monitoring of disease activity, inform treatment decisions, and aid in prognostication, as is now possible for idiopathic MN caused by antibodies against the phospholipase A2 receptor. Here, we show evidence for  ...[more]

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