Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: Christian Poitras
LAB HEAD: Benoit Coulombe
PROVIDER: PXD026647 | Pride | 2022-06-27
REPOSITORIES: Pride
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OF_20190125_COU_01.raw | Raw | |||
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OF_20190125_COU_04.raw | Raw |
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Journal of proteome research 20220207 4
The PAQosome (particle for arrangement of quaternary structure) is a 12-subunit HSP90 co-chaperone involved in the biogenesis of several human protein complexes. Two mechanisms of client selection have previously been identified, namely, the selective recruitment of specific adaptors and the differential use of homologous core subunits. Here, we describe a third client selection mechanism by showing that RPAP3, one of the core PAQosome subunits, is phosphorylated at several Ser residues in HEK29 ...[more]