Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Frank Stein
LAB HEAD: Johannes Buchner
PROVIDER: PXD013955 | Pride | 2019-08-12
REPOSITORIES: Pride
Items per page: 1 - 5 of 104 |
Nature communications 20190809 1
The molecular chaperone Hsp90 is an important regulator of proteostasis. It has remained unclear why S. cerevisiae possesses two Hsp90 isoforms, the constitutively expressed Hsc82 and the stress-inducible Hsp82. Here, we report distinct differences despite a sequence identity of 97%. Consistent with its function under stress conditions, Hsp82 is more stable and refolds more efficiently than Hsc82. The two isoforms also differ in their ATPases and conformational cycles. Hsc82 is more processive a ...[more]