Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Schizosaccharomyces Pombe 927
SUBMITTER: Jose Navarrete Perea
LAB HEAD: Kathleen L. Gould, Ph.D.
PROVIDER: PXD026766 | Pride | 2023-07-20
REPOSITORIES: Pride
Action | DRS | |||
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Experimental_design.docx | Other | |||
Spombe_phosphorylationsites.tsv | Tabular | |||
Spombe_proteome_peptides.tsv | Tabular | |||
Spombe_proteome_proteins.tsv | Tabular | |||
checksum.txt | Txt |
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Molecular cell 20220329 11
CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe an evolutionarily conserved mechanism of CK1 activity: autophosphorylation of a threonine (T220 in human CK1δ) located at the N terminus of helix αG, proximal to the substrate binding cleft. Crystal structures and molecular dynamics simulations uncovered inherent plasticity in αG that increased ...[more]