Dataset Information
Analysis of ERalpha PPI in breast cancer cells by LC-MS/MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): nanoACQUITY UPLC, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: 
Antonio Strillacci
LAB HEAD: Jacqueline Bromberg
PROVIDER: PXD027088 | Pride | 2022-08-30
REPOSITORIES: Pride
Dataset's files
Items per page: 1 - 5 of 25 |
Publications
ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance.
NPJ breast cancer 20220823 1
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is a widely utilized and successful strategy for breast cancer prevention and treatment. However, resistance to this endocrine therapy is frequently encountered and may occur through bypass or reactivation of ER-regulated transcriptional programs. We now identif ...[more]
