Ontology highlight
ABSTRACT:
INSTRUMENT(S): 5800 TOF/TOF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Qinming Chen
LAB HEAD: Lars Nordenskiold
PROVIDER: PXD027150 | Pride | 2021-08-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
H4K20me0.t2d | Other | |||
H4K20me0.tif | Other | |||
H4K20me0.txt | Txt | |||
H4K20me3.t2d | Other | |||
H4K20me3.tif | Other |
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Shoaib Muhammad M Chen Qinming Q Shi Xiangyan X Nair Nidhi N Prasanna Chinmayi C Yang Renliang R Walter David D Frederiksen Klaus S KS Einarsson Hjorleifur H Svensson J Peter JP Liu Chuan Fa CF Ekwall Karl K Lerdrup Mads M Nordenskiöld Lars L Sørensen Claus S CS
Nature communications 20210820 1
Histone lysine methylations have primarily been linked to selective recruitment of reader or effector proteins that subsequently modify chromatin regions and mediate genome functions. Here, we describe a divergent role for histone H4 lysine 20 mono-methylation (H4K20me1) and demonstrate that it directly facilitates chromatin openness and accessibility by disrupting chromatin folding. Thus, accumulation of H4K20me1 demarcates highly accessible chromatin at genes, and this is maintained throughout ...[more]