Proteomics

Dataset Information

0

MALDI-TOF Profiling of modified histone proteins


ABSTRACT: Histone lysine methylations as one of the chromatin post-translational modifications, has been linked to the modification of chromatin regions and mediating genome functions.In this study, we investigated the divergent role for histone H4 lysine 20 mono-methylation (H4K20me1) in facilitates chromatin openness and accessibility by disrupting chromatin folding.

INSTRUMENT(S): 5800 TOF/TOF

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Qinming Chen  

LAB HEAD: Lars Nordenskiold

PROVIDER: PXD027150 | Pride | 2021-08-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
H4K20me0.t2d Other
H4K20me0.tif Other
H4K20me0.txt Txt
H4K20me3.t2d Other
H4K20me3.tif Other
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Publications

Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes.

Shoaib Muhammad M   Chen Qinming Q   Shi Xiangyan X   Nair Nidhi N   Prasanna Chinmayi C   Yang Renliang R   Walter David D   Frederiksen Klaus S KS   Einarsson Hjorleifur H   Svensson J Peter JP   Liu Chuan Fa CF   Ekwall Karl K   Lerdrup Mads M   Nordenskiöld Lars L   Sørensen Claus S CS  

Nature communications 20210820 1


Histone lysine methylations have primarily been linked to selective recruitment of reader or effector proteins that subsequently modify chromatin regions and mediate genome functions. Here, we describe a divergent role for histone H4 lysine 20 mono-methylation (H4K20me1) and demonstrate that it directly facilitates chromatin openness and accessibility by disrupting chromatin folding. Thus, accumulation of H4K20me1 demarcates highly accessible chromatin at genes, and this is maintained throughout  ...[more]

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