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Trypanosoma brucei Trypanothione synthetase modification by Ebselen

ABSTRACT: Identification of Ebselen modification sites on T. brucei Trypanothione synthetase

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Escherichia Coli Trypanosoma Brucei

DISEASE(S): Trypanosomiasis

SUBMITTER: Rosario Durán

LAB HEAD: Rosario Durán

PROVIDER: PXD027729 | Pride | 2022-04-04

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	200710_Ecoli_strainB_BL21-DE3_4156sequences_TbTryS_T_brucei.fasta	Fasta
	200922_Control_2.raw	Raw
	200922_EbSe_1.raw	Raw
	200922_EbSe_2.raw	Raw
	200922_control_1.raw	Raw

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Publications

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening.

Benítez Diego D Franco Jaime J Sardi Florencia F Leyva Alejandro A Durán Rosario R Choi Gahee G Yang Gyongseon G Kim Taehee T Kim Namyoul N Heo Jinyeong J Kim Kideok K Lee Honggun H Choi Inhee I Radu Constantin C Shum David D No Joo Hwan JH Comini Marcelo A MA

Journal of enzyme inhibition and medicinal chemistry 20221201 1

Trypanothione synthetase (TryS) catalyses the synthesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular target for drug development against pathogens causing severe and fatal diseases in mammals. A drug discovery campaign aimed to identify and characterise new inhibitors of TryS with promising biological activity was cond ...[more]

PMID: 35306933

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Physicochemical and proteomic characterization reveals a remodeling of Escherichia coli and Proteus mirabilis outer membrane vesicles obtained under culture conditions mimicking urine growth

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