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Proteome landscape of schizophrenia in patient-derived cerebral organoids

ABSTRACT: We utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. cz organoids principally differed not in their proteomic diversity, but specifically in their total quantity of disease and neurodevelopmental factors at the molecular level. Provides unique insights into the proteome landscape of schizophrenia in patient-derived cerebral organoids

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Disease Free

SUBMITTER: david greening

LAB HEAD: david greening

PROVIDER: PXD027812 | Pride | 2021-11-17

REPOSITORIES: Pride

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			Action	DRS
	MN672_MN713_Combined_ProteinGroups.xlsx	Xlsx
	MN672_ProteinGroups.xlsx	Xlsx
	MN713_ProteinGroups.xlsx	Xlsx
	Sample_labelling_guide.xlsx	Xlsx
	checksum.txt	Txt

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