Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: David Wright
LAB HEAD: Patrick O'Donoghue
PROVIDER: PXD027882 | Pride | 2022-02-17
REPOSITORIES: Pride
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pp_2021_008_-A5A.raw | Raw | |||
pp_2021_008__A5A.raw | Raw | |||
ptmprofile_no_asa.csv | Csv | |||
with_asa_high_hit_peptide.csv | Csv |
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Wright David E DE Panaseiko Nikolaus N O'Donoghue Patrick P
Frontiers in chemistry 20210915
Thioredoxin Reductase 1 (TrxR1) is an enzyme that protects human cells against reactive oxygen species generated during oxidative stress or in response to chemotherapies. Acetylation of TrxR1 is associated with oxidative stress, but the function of TrxR1 acetylation in oxidizing conditions is unknown. Using genetic code expansion, we produced recombinant and site-specifically acetylated variants of TrxR1 that also contain the non-canonical amino acid, selenocysteine, which is essential for TrxR1 ...[more]