Dataset Information

Integrator complex subunit 7 (INTS7) immunocoprecipitation (IP) LC-MS/MS

ABSTRACT: To identify proteins that interact with INTS7 in BM-MSCs, IP experiments were performed and subjected to three independently LC-MS/MS analysis and Label-free quantification

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Stem Cell, Cell Culture

SUBMITTER: Yueshuai Guo

LAB HEAD: Yaozeng Xu

PROVIDER: PXD028817 | Pride | 2022-02-16

REPOSITORIES: pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	InGel-IgG-1-zb-20200902.raw	Raw
	InGel-IgG-2-zb-20200902.raw	Raw
	InGel-IgG-20200817.raw	Raw
	InGel-Ints7-1-zb-20200902.raw	Raw
	InGel-Ints7-2-zb-20200902.raw	Raw

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Publications

INTS7-ABCD3 Interaction Stimulates the Proliferation and Osteoblastic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Suppressing Oxidative Stress.

Liu Yubo Y Yu Xiao X Huang Anquan A Zhang Xiangxin X Wang Yijun Y Geng Wei W Xu Renjie R Li Suoyuan S He Hui H Zheng Bo B Chen Guangxiang G Xu Yaozeng Y

Frontiers in physiology 20211122

Increased adipocyte and decreased osteoblast differentiation, combined with the ectopic proliferation of bone marrow mesenchymal stem cells (BM-MSCs), represent the primary causes of osteoporosis. The dysregulation of numerous intracellular bioactive factors is responsible for the aberrant differentiation and growth of BM-MSCs. In this study, we focused on a new stimulative factor, integrator complex subunit 7 (INTS7), and its cooperative protein ATP-binding cassette subfamily D member 3 (ABCD3) ...[more]

PMID: 34880777

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