Dataset Information

Long-term nutritional regulation of liver proteome

ABSTRACT: Nutrient sensing pathways influence metabolic health and aging, offering the possibility that diet might be used therapeutically, alone or with drugs targeting these pathways. We used the Geometric Framework for Nutrition to study interactive and comparative effects of diet and drugs on the hepatic proteome in mice across 40 dietary treatments differing in macronutrient ratios, energy density, and drug treatment (metformin, rapamycin, resveratrol).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Benjamin Parker

LAB HEAD: Benjamin Parker

PROVIDER: PXD028928 | Pride | 2021-12-13

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20181003_Fusion_BenP_SimpsonPathway_TMT10_F1.raw	Raw
	20181003_Fusion_BenP_SimpsonPathway_TMT10_F10.raw	Raw
	20181003_Fusion_BenP_SimpsonPathway_TMT10_F11.raw	Raw
	20181003_Fusion_BenP_SimpsonPathway_TMT10_F12.raw	Raw
	20181003_Fusion_BenP_SimpsonPathway_TMT10_F2.raw	Raw

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Publications

Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin.

Le Couteur David G DG Solon-Biet Samantha M SM Parker Benjamin L BL Pulpitel Tamara T Brandon Amanda E AE Hunt Nicholas J NJ Wali Jibran A JA Gokarn Rahul R Senior Alistair M AM Cooney Gregory J GJ Raubenheimer David D Cogger Victoria C VC James David E DE Simpson Stephen J SJ

Cell metabolism 20211111 12

Nutrient sensing pathways influence metabolic health and aging, offering the possibility that diet might be used therapeutically, alone or with drugs targeting these pathways. We used the Geometric Framework for Nutrition to study interactive and comparative effects of diet and drugs on the hepatic proteome in mice across 40 dietary treatments differing in macronutrient ratios, energy density, and drug treatment (metformin, rapamycin, resveratrol). There was a strong negative correlation between ...[more]

PMID: 34767745

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