Dataset Information

Liver Proteomics of the Hybrid Mouse Diversity Panel

ABSTRACT: Hepatosteatosis underlies several diseases including type 2 diabetes, cardiovascular disease and liver disease. Unfortunately, our understanding of the contributing pathways that initiate and advance hepatosteatosis to subsequent complications is still poorly understood. Here, we take advantage of recent developments in “omics” technologies to perform high resolution proteomics (>5000 proteins) and quantitative lipidomics (>300 lipids) on livers from 107 genetically diverse inbred mouse strains from the hybrid mouse diversity panel. Integration of these data allowed us to define novel regulators of lipid metabolism in the liver.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Benjamin Parker

LAB HEAD: Benjamin Parker

PROVIDER: PXD010818 | Pride | 2019-03-05

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	150214_Fusion_BP_HMDP_TMT1_1.raw	Raw
	150214_Fusion_BP_HMDP_TMT1_10.raw	Raw
	150214_Fusion_BP_HMDP_TMT1_11.raw	Raw
	150214_Fusion_BP_HMDP_TMT1_2.raw	Raw
	150214_Fusion_BP_HMDP_TMT1_3.raw	Raw

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Publications

An integrative systems genetic analysis of mammalian lipid metabolism.

Parker Benjamin L BL Calkin Anna C AC Seldin Marcus M MM Keating Michael F MF Tarling Elizabeth J EJ Yang Pengyi P Moody Sarah C SC Liu Yingying Y Zerenturk Eser J EJ Needham Elise J EJ Miller Matthew L ML Clifford Bethan L BL Morand Pauline P Watt Matthew J MJ Meex Ruth C R RCR Peng Kang-Yu KY Lee Richard R Jayawardana Kaushala K Pan Calvin C Mellett Natalie A NA Weir Jacquelyn M JM Lazarus Ross R Lusis Aldons J AJ Meikle Peter J PJ James David E DE de Aguiar Vallim Thomas Q TQ Drew Brian G BG

Nature 20190227 7747

Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and progression of hepatosteatosis and metabolic syndrome. These conditions are highly prevalent in developed societies and currently have limited options for diagnostic and therapeutic intervention. Here, using a proteomic and lipidomic-wide systems genetic approach, we interrogated lipid regulatory networks in 107 genetically distinct mouse strains to reveal key insights into the control and network structure of ma ...[more]

PMID: 30814737

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