Proteomic analysis of human SKBR3/HER2+ breast cancer cell-surface proteins by using tryptic shaving
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ABSTRACT: The plasma membrane proteome resides at the interface between the extra- and intra-cellular environment and through its various roles in signal transduction, immune recognition, nutrient transport, and cell-cell and cell-matrix interactions plays a critical role in determining the fate of a cell. The objective of this study was to characterize the cell-membrane proteome of SKBR3/HER2+ breast cancer cells by using mass spectrometry detection, to advance the understanding of biological triggers that sustain aberrant cell survival, proliferation, and development of resistance to therapeutic drugs.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Arba Karcini
LAB HEAD: Iulia M. Lazar
PROVIDER: PXD028978 | Pride | 2022-07-11
REPOSITORIES: Pride
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