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Citrullinated epitopes identified on tumor MHC class II by peptide elution stimulate both regulatory and Th1 responses and require careful selection for optimal tumor therapy

ABSTRACT: In this manuscript, we outline the identification of citrullinated peptide epitopes presented on the surface of tumor cells that can be targeted for tumor therapy. Peptide elution from MHC is a useful tool in the identification of novel targets and has been used by many in immunotherapy strategies. Here we describe the identification of post-translationally modified citrullinated peptides through elution from MHC class II molecules.

INSTRUMENT(S): LTQ Orbitrap XL

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Ana Marcu

LAB HEAD: Lindy G Durrant

PROVIDER: PXD029029 | Pride | 2021-11-24

REPOSITORIES: Pride

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			Action	DRS
	180518_AM_Mouse_HHD_HLA-DP4_Tumor_Tue39L243_CoPro.msf	Msf
	180518_AM_Mouse_HHD_HLA-DP4_Tumor_Tue39L243_CoPro_Peptides.xlsx	Xlsx
	180518_AM_Mouse_HHD_HLA-DP4_Tumor_Tue39L243_Rep1_msms9.msf	Msf
	180518_AM_Mouse_HHD_HLA-DP4_Tumor_Tue39L243_Rep1_msms9.raw	Raw
	180518_AM_Mouse_HHD_HLA-DP4_Tumor_Tue39L243_Rep1_msms9_Peptides.xlsx	Xlsx

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