Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Xu-Dong Wang
LAB HEAD: Yonghao Yu
PROVIDER: PXD029968 | Pride | 2024-01-26
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
20210110_SCLC_Batch2.xlsx | Xlsx | |||
20210121_SCLC_Batch3.xlsx | Xlsx | |||
20210121_SCLC_Batch4.xlsx | Xlsx | |||
20210209_SCLC_Batch5.xlsx | Xlsx | |||
20210210_SCLC_Batch6.xlsx | Xlsx |
Items per page: 1 - 5 of 90 |
Science advances 20240119 3
Although <i>BRCA1/2</i> mutations are not commonly found in small cell lung cancer (SCLC), a substantial fraction of SCLC shows clinically relevant response to PARP inhibitors (PARPis). However, the underlying mechanism(s) of PARPi sensitivity in SCLC is poorly understood. We performed quantitative proteomic analyses and identified proteomic changes that signify PARPi responses in SCLC cells. We found that the vulnerability of SCLC to PARPi could be explained by the degradation of lineage-specif ...[more]