Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Romain Hamelin
LAB HEAD: Serge ROCHE
PROVIDER: PXD030006 | Pride | 2022-01-14
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
EA_170504_HF_3A1_01.raw | Raw | |||
EA_170504_HF_3A1_02.raw | Raw | |||
EA_170504_HF_3A2_01.raw | Raw | |||
EA_170504_HF_3A2_02.raw | Raw | |||
EA_170504_HF_Ctrl1_01.raw | Raw |
Items per page: 1 - 5 of 14 |
Oncogene 20220109 7
The membrane-anchored Src tyrosine kinase is involved in numerous pathways and its deregulation is involved in human cancer. Our knowledge on Src regulation relies on crystallography, which revealed intramolecular interactions to control active Src conformations. However, Src contains a N-terminal intrinsically disordered unique domain (UD) whose function remains unclear. Using NMR, we reported that UD forms an intramolecular fuzzy complex involving a conserved region with lipid-binding capacity ...[more]