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The E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron

ABSTRACT: We identify cyclic imides, previously overlooked post-translation modifications, across different tissues (red blood cells and bovine lens) and human-derived cell lines and found that these modifications are globally regulated by cereblon.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Bos Taurus (bovine)

TISSUE(S): Erythrocyte, Eye, Cell Suspension Culture, Plasma Cell, Early Embryonic Cell, Cell Culture, Blood

SUBMITTER: Christina Woo

LAB HEAD: Christina Woo

PROVIDER: PXD030091 | Pride | 2022-07-28

REPOSITORIES: Pride

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The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron.

Ichikawa Saki S Flaxman Hope A HA Xu Wenqing W Vallavoju Nandini N Lloyd Hannah C HC Wang Binyou B Shen Dacheng D Pratt Matthew R MR Woo Christina M CM

Nature 20221019 7933

The ubiquitin E3 ligase substrate adapter cereblon (CRBN) is a target of thalidomide and lenalidomide1, therapeutic agents used in the treatment of haematopoietic malignancies2-4 and as ligands for targeted protein degradation5-7. These agents are proposed to mimic a naturally occurring degron; however, the structural motif recognized by the thalidomide-binding domain of CRBN remains unknown. Here we report that C-terminal cyclic imides, post-translational modifi ...[more]

PMID: 36261529

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			Action	DRS
	Bovine_lens.msf	Msf
	Bovinelens-fr1.raw	Raw
	Bovinelens-fr2.raw	Raw
	Bovinelens-fr3.raw	Raw
	Bovinelens-fr4.raw	Raw