Dataset Information
Hypoxia-Induced Regulation of the Proteome in Multiple Myeloma Cell Lines
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Plasma Cell
DISEASE(S): Multiple Myeloma
SUBMITTER: 
Frank Schnütgen
LAB HEAD: Hubert Serve
PROVIDER: PXD030239 | Pride | 2022-02-16
REPOSITORIES: pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| File_index.txt | Txt | |||
| MaxQuant_Output.7z | Other | |||
| TO_N_Kurrle_010617_010817_Gel3_L12_1.raw | Raw | |||
| TO_N_Kurrle_010617_010817_Gel3_L12_10.raw | Raw | |||
| TO_N_Kurrle_010617_010817_Gel3_L12_11.raw | Raw |
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Publications
Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene.
Cells 20220115 2
Multiple myeloma (MM) is the second most common hematologic malignancy, which is characterized by clonal proliferation of neoplastic plasma cells in the bone marrow. This microenvironment is characterized by low oxygen levels (1-6% O<sub>2</sub>), known as hypoxia. For MM cells, hypoxia is a physiologic feature that has been described to promote an aggressive phenotype and to confer drug resistance. However, studies on hypoxia are scarce and show little conformity. Here, we analyzed the mRNA exp ...[more]
