Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Cadasil
SUBMITTER: Kelly Young
LAB HEAD: Michael M. Wang
PROVIDER: PXD031097 | Pride | 2022-05-20
REPOSITORIES: Pride
Action | DRS | |||
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PRF_Q_2019_M_WANG_89_47567.msf | Msf | |||
PRF_Q_2019_M_WANG_89_47567.raw | Raw | |||
PRF_Q_2019_M_WANG_89_47568.msf | Msf | |||
PRF_Q_2019_M_WANG_89_47568.raw | Raw | |||
PRF_Q_2019_M_WANG_89_47569.msf | Msf |
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Communications biology 20220407 1
Cerebral small vessel disease (SVD) is a prevalent disease of aging and a major contributor to stroke and dementia. The most commonly inherited SVD, CADASIL, is caused by dominantly acting cysteine-altering mutations in NOTCH3. These mutations change the number of cysteines from an even to an odd number, but the impact of these alterations on NOTCH3 protein structure remain unclear. Here, we prepared wildtype and four mutant recombinant NOTCH3 protein fragments to analyze the impact of CADASIL m ...[more]