Dataset Information
Protein interactions with GFP-tagged cytoplasmic dynein-2 DATASET2
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: 
David Stephens
LAB HEAD: David Stephens
PROVIDER: PXD031158 | Pride | 2023-01-24
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 201115_Con_v_IC2_v_WDR34_v_WDR60.xlsx | Xlsx | |||
| 201115_Control_Pooled_1-6.msf | Msf | |||
| 201115_IC2_Pooled_1-6.msf | Msf | |||
| 201115_WDR34_Pooled_1-6.msf | Msf | |||
| 201115_WDR60_Pooled_1-6.msf | Msf |
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Publications
Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective intraflagellar transport.
Journal of cell science 20230207 5
The dynein-2 complex must be transported anterogradely within cilia to then drive retrograde trafficking of the intraflagellar transport (IFT) machinery containing IFT-A and IFT-B complexes. Here, we screened for potential interactions between the dynein-2 and IFT-B complexes and found multiple interactions among the dynein-2 and IFT-B subunits. In particular, WDR60 (also known as DYNC2I1) and the DYNC2H1-DYNC2LI1 dimer from dynein-2, and IFT54 (also known as TRAF3IP1) and IFT57 from IFT-B contr ...[more]
