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Raw data for "Dynamic mitochondrial proteome under polyamines treatment in cardiac aging"

ABSTRACT: In this study, we found that spermine (Spm) and spermidine (Spd) injection for 6 weeks could prevent 24-month old rats heart dysfunction，improve mitochondrial function and down-regulate apoptosis. Using iTRAQ tools, we identify 75 mitochondrial proteins of statistically significant alteration in aging hearts, which mainly participate in important mitochondrial physiological activity, such as metabolism, translation, transport, apoptosis and oxidative phosphorylation.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart

SUBMITTER: Hao Zhang

LAB HEAD: Yajun Zhao

PROVIDER: PXD031270 | Pride | 2022-05-20

REPOSITORIES: pride

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Dynamic Mitochondrial Proteome Under Polyamines Treatment in Cardiac Aging.

Zhang Hao H Yan Meng M Liu Ting T Wei Peiling P Chai Nannan N Li Lingxu L Wang Junying J Yu Xue X Lin Yan Y Qiu Bintao B Zhao Yajun Y

Frontiers in cell and developmental biology 20220315

Age-related alteration of mitochondria causes impaired cardiac function, along with cellular and molecular changes. Polyamines can extend the life span in mice. However, whether polyamines can affect the dynamic mitochondrial proteome, thereby preventing age-related changes in cardiac function and cardiac aging, remains unclear. In this study, we found that spermine (Spm) and spermidine (Spd) injection for 6 weeks could prevent 24-month-old rats heart dysfunction, improve mitochondrial function, ...[more]

PMID: 35372351

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