Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Nikiana Simigdala
LAB HEAD: Lesley-Ann Martin
PROVIDER: PXD031377 | Pride | 2023-03-10
REPOSITORIES: Pride
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Experimental_design_all.xlsx | Xlsx | |||
QE05349.raw | Raw | |||
QE05351.raw | Raw | |||
QE05353.raw | Raw | |||
QE05355.raw | Raw |
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NPJ breast cancer 20221129 1
The selective oestrogen receptor (ER) degrader (SERD), fulvestrant, is limited in its use for the treatment of breast cancer (BC) by its poor oral bioavailability. Comparison of the orally bioavailable investigational SERD elacestrant, versus fulvestrant, demonstrates both drugs impact tumour growth of ER+ patient-derived xenograft models harbouring several ESR1 mutations but that elacestrant is active after acquired resistance to fulvestrant. In cell line models of endocrine sensitive and resis ...[more]