Dataset Information
Effects of VLK knockout on the proteome of primary mouse hepatocytes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Hepatocyte, Liver
SUBMITTER: 
Joern Dengjel
LAB HEAD: Joern Dengjel
PROVIDER: PXD031378 | Pride | 2022-03-24
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 20200515_ZH_Mouse_TCA_1_20200516195956.raw | Raw | |||
| 20200515_ZH_Mouse_TCA_2.raw | Raw | |||
| 20200515_ZH_Mouse_TCA_3.raw | Raw | |||
| 20200515_ZH_Mouse_TCA_4.raw | Raw | |||
| 20200515_ZH_Mouse_TCA_5.raw | Raw |
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Publications
Vertebrate lonesome kinase modulates the hepatocyte secretome to prevent perivascular liver fibrosis and inflammation.
Journal of cell science 20220412 7
Vertebrate lonesome kinase (VLK) is the only known extracellular tyrosine kinase, but its physiological functions are largely unknown. We show that VLK is highly expressed in hepatocytes of neonatal mice, but downregulated during adulthood. To determine the role of VLK in liver homeostasis and regeneration, we generated mice with a hepatocyte-specific knockout of the VLK gene (Pkdcc). Cultured progenitor cells established from primary hepatocytes of Pkdcc knockout mice produced a secretome, whic ...[more]
