Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: John R. Engen
LAB HEAD: John R. Engen
PROVIDER: PXD031508 | Pride | 2022-08-09
REPOSITORIES: Pride
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1_052218_FN9_10_10minD2O.raw.zip | Raw | |||
1_052218_FN9_10_10secD2O.raw.zip | Raw | |||
1_052218_FN9_10_1minD2O.raw.zip | Raw | |||
1_052218_FN9_10_4hD2O.raw.zip | Raw | |||
1_052218_FN9_10_60minD2O.raw.zip | Raw |
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The Journal of biological chemistry 20220802 9
Integrin α5β1 mediates cell adhesion to the extracellular matrix by binding fibronectin (Fn). Selectivity for Fn by α5β1 is achieved through recognition of an RGD motif in the 10th type III Fn domain (Fn10) and the synergy site in the ninth type III Fn domain (Fn9). However, details of the interaction dynamics are unknown. Here, we compared synergy-site and Fn-truncation mutations for their α5β1-binding affinities and stabilities. We also interrogated binding of the α5β1 ectodomain headpiece fra ...[more]