Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Retinal Pigment Epithelium Cell Line, Epithelial Cell
SUBMITTER: Kirk West
LAB HEAD: Justin Wai
PROVIDER: PXD031714 | Pride | 2024-07-19
REPOSITORIES: Pride
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Li Junshi J Xiong Nan N West Kirk L KL Leung Manton M Ching Yick Pang YP Huang Jun J Yuan Jian J Yu Cheng-Han CH Leung Justin J Huen Michael M
Nucleic acids research 20240801 15
Nuclear actin-based movements support DNA double-strand break (DSB) repair. However, molecular determinants that promote filamentous actin (F-actin) formation on the damaged chromatin remain undefined. Here we describe the DYRK1A kinase as a nuclear activity that promotes local F-actin assembly to support DSB mobility and repair, accomplished in part by its targeting of actin nucleator spire homolog 1 (Spir1). Indeed, perturbing DYRK1A-dependent phosphorylation of S482 mis-regulated Spir1 accumu ...[more]